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This can occur when homologous X chromosomes fail to separate in the formation of the egg or sperm.

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Many also show joint and muscle tone abnormalities, including hypotonia and joint looseness in the hips.

Skeletal problems may also be present, including abnormal curvatures of the spine.

An informal study conducted by Tetrasomy & Pentasomy X Syndrome Information and Support found that 10% of girls had joint laxity in the hips and 20% had joint limitations in a sample size of 20 tetrasomy and pentasomy patients.

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XXXX syndrome (also called tetrasomy X, quadruple X, or 48, XXXX) is a rare chromosomal disorder caused by the presence of four X chromosomes instead of two X chromosomes.

This condition occurs only in females, as there are no Y chromosomes present.

Tetrasomy X was first described in 1961, and since then approximately 100 cases have been reported worldwide.

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